Cancer Conundrum
نویسندگان
چکیده
The main event is when physiologic EMT is seen in gastrulation; formation and migration of neural crest cells.[3] The progression of EMT is further classified into primary (1°), secondary (2°) and tertiary (3°) EMT,[2] depending on the number or sequential sweeps of EMT and mesenchymal‐epithelial transition (MET).[2] MET signifies the conversion of the mesenchymal phenotype back into the epithelial phenotype. • 1° ‐ Gastrulation, neural crest development • 2° ‐ Somite formation, palatogenesis, formation of liver, pancreas and reproductive tract • 3° ‐ Heart development.
منابع مشابه
The Obesity-Breast Cancer Conundrum: An Analysis of the Issues
Breast cancer develops over a timeframe of 2-3 decades prior to clinical detection. Given this prolonged latency, it is somewhat unexpected from a biological perspective that obesity has no effect or reduces the risk for breast cancer in premenopausal women yet increases the risk for breast cancer in postmenopausal women. This conundrum is particularly striking in light of the generally negativ...
متن کاملThe Conundrum of Online Prescription Drug Promotion; Comment on “Trouble Spots in Online Direct-to-Consumer Prescription Drug Promotion: A Content Analysis of FDA Warning Letters”
This commentary discusses pertinent issues from Hyosun Kim’s paper on online prescription drug promotion. The study is well-designed and the findings highlight some of the consequences of the Food and Drug Administration’s (FDA’s) decision to deregulate online advertising of prescription drugs. While Kim’s findings confirm some of the early concerns, they also provide a perspective of implement...
متن کاملImproved survival and higher mortality: the conundrum of lung cancer screening.
Abbreviations: CG control group; CR chest radiograph; ELCAP Early Lung Cancer Detection Project; FN false negative; FP false positive; HRCT high-resolution CT; IG intervention group; LC lung cancer; LCM lung cancer mortality; LDCT screening helical low-dose CT; MLP Mayo Lung Project; mSv millisieverts; NSCLC nonsmall cell lung cancer; SCR screening chest radiograph; TN true negative; TP true po...
متن کاملThe conundrum of the young colon cancer patient.
BACKGROUND Colonoscopy has had a major impact on the incidence and survival of colon cancer for patients who are screened, usually beginning at the age of 50. Meanwhile, the incidence rate of colon cancer is actually increasing in the patients younger than 50 while no routine screening is implemented for this age group. METHODS All patients surgically treated for colon cancer (2004-2011) with...
متن کاملThe paradox of dicer in cancer
Dicer has been well studied in cancer; however, deciphering its exact function in tumorigenesis continues to be a challenge. While partial suppression or truncation of Dicer promotes tumorigenesis, its complete deletion inhibits tumor growth. Here, we discuss this Dicer cancer conundrum in the context of its recently discovered role in the DNA damage response.
متن کامل